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1

Recent advances in the discovery and development of topoisomerase inhibitors as antitumor agents

Hui-Kang Wang, Susan L. Morris-Natschke, Kuo-Hsiung Lee

Journal:

Medicinal Research Reviews

Year:

1997

Language:

english

File:

PDF, 1.49 MB

english, 1997

2

Anti-AIDS Agents. 48.1 Anti-HIV Activity of Moronic Acid Derivatives and the New Melliferone-Related Triterpenoid Isolated from Brazilian Propolis

Ito, Junko, Chang, Fang-Rong, Wang, Hui-Kang, Park, Yong Kun, Ikegaki, Masaharu, Kilgore, Nicole, Lee, Kuo-Hsiung

Journal:

Journal of Natural Products

Year:

2001

Language:

english

File:

PDF, 99 KB

english, 2001

3

Anti-AIDS agents. 32.1 synthesis and anti-HIV activity of betulin derivatives

I-Chen Sun, Jing-Kang Shen, Hui-Kang Wang, L.Mark Cosentino, Kuo-Hsiung Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 249 KB

english, 1998

4

Antitumor Agents. Part 214: Synthesis and Evaluation of Curcumin Analogues as Cytotoxic Agents

Junko Ishida, Hironori Ohtsu, Yoko Tachibana, Yuka Nakanishi, Kenneth F Bastow, Masahiro Nagai, Hui-Kang Wang, Hideji Itokawa, Kuo-Hsiung Lee

Journal:

Bioorganic & Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 187 KB

english, 2002

5

Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids1

Kashiwada, Yoshiki, Wang, Hui-Kang, Nagao, Tsuneatsu, Kitanaka, Susumu, Yasuda, Ichiro, Fujioka, Toshihiro, Yamagishi, Takashi, Cosentino, L. Mark, Kozuka, Mutsuo, Okabe, Hikaru

Journal:

Journal of Natural Products

Year:

1998

Language:

english

File:

PDF, 117 KB

english, 1998

6

Enhanced cycling performance and high energy density of LiFePO4 based lithium ion batteries

Yi-Jie Gu, Cui-Song Zeng, Hui-Kang Wu, Hong-Zhi Cui, Xiao-Wen Huang, Xiu-Bo Liu, Cui-Ling Wang, Zhi-Ning Yang, Hong Liu

Journal:

Materials Letters

Year:

2007

Language:

english

File:

PDF, 647 KB

english, 2007

7

Antitumor Agents. 217.† Curcumin Analogues as Novel Androgen Receptor Antagonists with Potential as Anti-Prostate Cancer Agents

Ohtsu, Hironori, Xiao, Zhiyan, Ishida, Junko, Nagai, Masahiro, Wang, Hui-Kang, Itokawa, Hideji, Su, Ching-Yuan, Shih, Charles, Chiang, Tzuying, Chang, Eugene

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 123 KB

english, 2002

8

Identification of ent -16β,17-Dihydroxykauran-19-oic Acid as an Anti-HIV Principle and Isolation of the New Diterpenoids Annosquamosins A and B from Annona squamosa

Wu, Yang-Chang, Hung, Yu-Chun, Chang, Fang-Rong, Cosentino, Mark, Wang, Hui-Kang, Lee, Kuo-Hsiung

Journal:

Journal of Natural Products

Year:

1996

Language:

english

File:

PDF, 143 KB

english, 1996

9

ChemInform Abstract: Anti-AIDS Agents. Part 34. Synthesis and Structure—Activity Relationships of Betulin Derivatives as Anti-HIV Agents.

I-Chen Sun, Hui-Kang Wang, Yoshiki Kashiwada, Jing-Kang Shen, L. Mark Cosentino, Chin-Ho Chen, Li-Ming Yang, Kuo-Hsiung Lee

Journal:

Year:

1999

File:

PDF, 35 KB

1999

10

ChemInform Abstract: Synthesis and Anti-HIV Activity of Oleanolic Acid Derivatives.

Yong-Ming Zhu, Jing-Kang Shen, Hui-Kang Wang, L. Mark Cosentino, Kuo-Hsiung Lee

Journal:

Year:

2002

File:

PDF, 31 KB

2002

11

ChemInform Abstract: Antitumor Agents. Part 209. Pheophorbide-a Derivatives as Photo-Independent Cytotoxic Agents.

Prapai Wongsinkongman, Arnold Brossi, Hui-Kang Wang, Kenneth F. Bastow, Kuo-Hsiung Lee

Journal:

Year:

2002

File:

PDF, 35 KB

2002

12

Chemistry of Taxol and Related Taxoids

Hui-Kang Wang, Hironori Ohtsu, Hideji Itokawa

Journal:

Year:

2004

File:

PDF, 49 KB

2004

13

Up-regulation of heat shock protein 70-1 (Hsp70-1) in human limbo-corneal epithelial cells cultivated on amniotic membrane: A proteomic study

David Hui-Kang Ma, Jui-Yang Lai, Szu-Tzu Yu, Jia-Ye Liu, Unique Yang, Hung-Chi Jesse Chen, Lung-Kung Yeh, Yi-Ju Ho, Grace Chang, Su-Fang Wang, Jan-Kan Chen, Ken-Kuo Lin

Journal:

Journal of Cellular Physiology

Year:

2012

Language:

english

File:

PDF, 717 KB

english, 2012

14

Antitumor agents. Part 235: Novel 4′-ester etoposide analogues as potent DNA topoisomerase II inhibitors with improved therapeutic potential

Zhiyan Xiao, John R Vance, Kenneth F Bastow, Arnold Brossi, Hui-Kang Wang, Kuo-Hsiung Lee

Journal:

Bioorganic & Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 358 KB

english, 2004

15

Synthesis and anti-HIV activity of oleanolic acid derivatives

Yong-Ming Zhu, Jing-Kang Shen, Hui-Kang Wang, L.Mark Cosentino, Kuo-Hsiung Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 124 KB

english, 2001

16

Novel water-solutle (7-(acylhydrazono)-formyl camptothecins as potent inhibitors of DNA topoisomerase I

Hui-Kang Wang, Su-Yin-Liu, Kou-Mao Hwang, Glen Taylor, Kuo-Hsiung Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 231 KB

english, 1994

17

Antitumor agents. 1771. Design, syntheses, and biological evaluation of novel etoposide analogs bearing pyrrolecarboxamidino group as DNA topoisomerase II inhibitors

Zheng Ji, Hui-Kang Wang, Kenneth F. Bastow, Xiao-Kang Zhu, Sung Jin Cho, Yung-Chi Cheng, Kuo-Hsiung Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 239 KB

english, 1997

18

Antitumor agents 201.1 Cytotoxicity of harmine and β-carboline analogs

Junko Ishida, Hui-Kang Wang, Kenneth F. Bastow, Chang-Qi Hu, Kuo-Hsiung Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 235 KB

english, 1999

19

Synthesis of novel water-soluble 7-(aminoacylhydrazono)-formyl camptothecins with potent inhibition of DNA topoisomerase I

Hui-Kang Wang, Su-Yin Liu, Kou-Maou Hwang, Glen Taylor, Kuo-Hsiung Lee

Journal:

Bioorganic & Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 780 KB

english, 1994

20

Antitumor agents. Part 209: Pheophorbide-a derivatives as photo-Independent cytotoxic agents

Prapai Wongsinkongman, Arnold Brossi, Hui-Kang Wang, Kenneth F. Bastow, Kuo-Hsiung Lee

Journal:

Bioorganic & Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 225 KB

english, 2002

21

The synthesis of 5-substituted camptothecins as potential inhibitors of DNA topoisomerase I

Hui-Kang Wang, Su-Yin Lin, Kou-Maou Hwang, Andrew T. McPhail, Kuo-Hsiung Lee

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 242 KB

english, 1995

22

Antitumor agents 210. synthesis and evaluation of taxoid–epipodophyllotoxin conjugates as novel cytotoxic agents

Qian Shi, Hui-Kang Wang, Kenneth F Bastow, Yoko Tachibana, Ke Chen, Fang-Yu Lee, Kuo-Hsiung Lee

Journal:

Bioorganic & Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 153 KB

english, 2001

23

Antitumor agents—CLXXIII. Synthesis and evaluation of camptothecin-4β-amino-4′-O-demethyl epipodophyllotoxin conjugates as inhibitors of mammalian DNA topoisomerases and as cytotoxic agents

Kenneth F. Bastow, Hui-Kang Wang, Yung-Chi Cheng, Kuo-Hsiung Lee

Journal:

Bioorganic & Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 728 KB

english, 1997

24

Synthesis and Cytotoxicity of Methyl-4,8-dihydrobenzo[1,2-b:5,4-b′]dithiophene-4,8-dione Derivatives

Yu-Hua Chao, Sheng-Chu Kuo, Kelvin Ku, I-Ping Chiu, Chun-Hsiung Wu, Anthony Mauger, Hui-Kang Wang, Kuo-Hsiung Lee

Journal:

Bioorganic & Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 181 KB

english, 1999

25

Anti-AIDS Agents. 34.† Synthesis and Structure−Activity Relationships of Betulin Derivatives as Anti-HIV Agents

Sun, I-Chen, Wang, Hui-Kang, Kashiwada, Yoshiki, Shen, Jing-Kang, Cosentino, L. Mark, Chen, Chin-Ho, Yang, Li-Ming, Lee, Kuo-Hsiung

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 186 KB

english, 1998

26

LC/TIS-MS Fingerprint Profiling of Cimicifuga Species and Analysis of 23-Epi-26-deoxyactein in Cimicifuga racemosa Commercial Products

Wang, Hui-Kang, Sakurai, Nokuko, Shih, Charles Y., Lee, Kuo-Hsiung

Journal:

Journal of Agricultural and Food Chemistry

Year:

2005

Language:

english

File:

PDF, 186 KB

english, 2005

27

Unique biochemical, cytotoxic, and antitumor activity of camptothecin and 4β-amino-4′-O-demethylepipodophyllotoxin conjugates

Jang-Yang Chang, Xin Guo, Hong-Xing Chen, Zaoli Jiang, Qin Fu, Hui-Kang Wang, Kenneth F. Bastow, Xiao-Kang Zhu, Jian Guan, Kuo-Hsiung Lee, Yung-Chi Cheng

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 499 KB

english, 2000

28

Antitumor 2,3-dihydro-2-(aryl)-4(1H)-quinazolinone derivatives: Interactions with tubulin

Ernest Hamel, Chii M. Lin, Jacqueline Plowman, Hui-Kang Wang, Kuo-Hsiung Lee, Kenneth D. Paull

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 755 KB

english, 1996

29

Structural characterization of layered LiNi0.85−xMnxCo0.15O2 with x = 0, 0.1, 0.2 and 0.4 oxide electrodes for Li batteries

Yi-Jie Gu, Yun-Bo Chen, Hong-Quan Liu, Yan-Ming Wang, Cui-Ling Wang, Hui-Kang Wu

Journal:

Journal of Alloys and Compounds

Year:

2011

Language:

english

File:

PDF, 604 KB

english, 2011

30

Antitumor-promoting effects of cyclic diarylheptanoids on Epstein–Barr virus activation and two-stage mouse skin carcinogenesis

Junko Ishida, Mutsuo Kozuka, Hui-Kang Wang, Takao Konoshima, Harukuni Tokuda, Masato Okuda, Xiao Yang Mou, Hoyoku Nishino, Nobuko Sakurai, Kuo-Hsiung Lee, Masahiro Nagai

Journal:

Year:

2000

Language:

english

File:

PDF, 141 KB

english, 2000

31

Anti-AIDS Agents 49. 1 Synthesis, Anti-HIV, and Anti-Fusion Activities of IC9564 Analogues Based on Betulinic Acid

Sun, I-Chen, Chen, Chin-Ho, Kashiwada, Yoshiki, Wu, Jiu-Hong, Wang, Hui-Kang, Lee, Kuo-Hsiung

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 102 KB

english, 2002

32

Matrix Revolution: Molecular Mechanism for Inflammatory Corneal Neovascularization and Restoration of Corneal Avascularity by Epithelial stem Cell Transplantation

David Hui-Kang, Hung-Chi Jesse, Jui-Yang Lai, Chi-Chin Sun, Su-Fang Wang, Ken-Kuo Lin, Jan-Kan Chen

Journal:

The Ocular Surface

Year:

2009

Language:

english

File:

PDF, 2.08 MB

english, 2009

33

Re-appraisal of N2 disease by lymphatic drainage pattern for non-small-cell lung cancers: By terms of nodal stations, zones, chains, and a composite

Zheng, Hui, Wang, Lin-mao, Bao, Fang, Jiang, Ge-ning, Xie, Hui-kang, Ding, Jia-an, Hu, Xue-fei, Chen, Chang

Journal:

Year:

2011

Language:

english

File:

PDF, 725 KB

english, 2011

34

Antitumor Agents. 166. Synthesis and Biological Evaluation of 5,6,7,8-Substituted-2-phenylthiochromen-4-ones †

Wang, Hui-Kang, Bastow, Kenneth F., Cosentino, L. Mark, Lee, Kuo-Hsiung

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 288 KB

english, 1996

35

The therapeutic potential of flavonoids

Journal:

Expert Opinion on Investigational Drugs

Year:

2000

Language:

english

File:

PDF, 126 KB

english, 2000

36

Novel Anti-HIV Lancilactone C and Related Triterpenes from Kadsura lancilimba

Chen, Dao-Feng, Zhang, Shun-Xiang, Wang, Hui-Kang, Zhang, Shi-Yuan, Sun, Quan-Zhong, Cosentino, L. Mark, Lee, Kuo-Hsiung

Journal:

Journal of Natural Products

Year:

1999

Language:

english

File:

PDF, 97 KB

english, 1999

37

Antitumor Agents, 138. Rotenoids and Isoflavones as Cytotoxic Constituents from Amorpha fruticosa

Li, Leping, Wang, Hui-Kang, Chang, Jer-Jang, McPhail, Andrew T., McPhail, Donald R., Terada, Hiroki, Konoshima, Takao, Kokumai, Midori, Kozuka, Mutsuo, Estes, James R., Lee, Kuo-Hsiung

Journal:

Journal of Natural Products

Year:

1993

Language:

english

File:

PDF, 531 KB

english, 1993

38

Cytotoxic Pheophorbide-Related Compounds from Clerodendrum c alamitosum and C. cyrtophyllum §

Cheng, Huey-Hwa, Wang, Hui-Kang, Ito, Junko, Bastow, Kenneth F., Tachibana, Yoko, Nakanishi, Yuka, Xu, Zhihong, Luo, Tsui-Yun, Lee, Kuo-Hsiung

Journal:

Journal of Natural Products

Year:

2001

Language:

english

File:

PDF, 57 KB

english, 2001

39

Antitumor Agents 155. Synthesis and Biological Evaluation of 3',6,7-Substituted 2-Phenyl-4-quinolones as Antimicrotubule Agents

Li, Leping, Wang, Hui-Kang, Kuo, Sheng-Chu, Wu, Tian-Shung, Mauger, Anthony, Lin, Chii M., Hamel, Ernest, Lee, Kuo-Hsiung

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 874 KB

english, 1994

40

Antitumor Agents. 150. 2',3',4',5',5,6,7-Substituted 2-Phenyl-4-quinolones and Related Compounds: Their Synthesis, Cytotoxicity, and Inhibition of Tubulin Polymerization

Li, Leping, Wang, Hui-Kang, Kuo, Sheng-Chu, Wu, Tian-Shung, Lednicer, Dan, Lin, Chii M., Hamel, Ernest, Lee, Kuo-Hsiung

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.33 MB

english, 1994

41

Anti-AIDS Agents. 46. 1 Anti-HIV Activity of Harman, an Anti-HIV Principle from Symplocos setchuensis , and Its Derivatives

Ishida, Junko, Wang, Hui-Kang, Oyama, Masayoshi, Cosentino, Mark L., Hu, Chang-Qi, Lee, Kuo-Hsiung

Journal:

Journal of Natural Products

Year:

2001

Language:

english

File:

PDF, 52 KB

english, 2001

42

Studies on Inhibitors of Skin Tumor Promotion, XII. Rotenoids from Amorpha fruticosa

Konoshima, Takao, Terada, Hiroki, Kokumai, Midori, Kozuka, Mutsuo, Tokuda, Harukuni, Estes, James R., Li, Leping, Wang, Hui-Kang, Lee, Kuo-Hsiung

Journal:

Journal of Natural Products

Year:

1993

Language:

english

File:

PDF, 323 KB

english, 1993

43

Anti-HIV Agents 45 1 and Antitumor Agents 205. 2 Two New Sesquiterpenes, Leitneridanins A and B, and the Cytotoxic and Anti-HIV Principles from Leitneria f loridana

Xu, Zhihong, Chang, Fang-Rong, Wang, Hui-Kang, Kashiwada, Yoshiki, McPhail, Andrew T., Bastow, Kenneth F., Tachibana, Yoko, Cosentino, Mark, Lee, Kuo-Hsiung

Journal:

Journal of Natural Products

Year:

2000

Language:

english

File:

PDF, 53 KB

english, 2000

44

Interiotherins C and D, Two New Lignans from Kadsura i nterior and Antitumor-Promoting Effects of Related Neolignans on Epstein−Barr Virus Activation

Chen, Dao-Feng, Zhang, Shun-Xiang, Kozuka, Mutsuo, Sun, Quan-Zhong, Feng, Ju, Wang, Qiang, Mukainaka, Teruo, Nobukuni, Yoshitaka, Tokuda, Harukuni, Nishino, Hoyoku, Wang, Hui-Kang, Morris-Natschke, Su

Journal:

Journal of Natural Products

Year:

2002

Language:

english

File:

PDF, 60 KB

english, 2002

45

Antitumor Agents. 234. † Design, Synthesis, and Biological Evaluation of Novel 4β-[(4‘ ‘-Benzamido)-Amino]-4‘- O -Demethyl-Epipodophyllotoxin Derivatives

Xiao, Zhiyan, Bastow, Kenneth F., Vance, John R., Sidwell, Robert S., Wang, Hui-Kang, Chen, Ming S., Shi, Qian, Lee, Kuo-Hsiung

Journal:

Journal of Medicinal Chemistry

Year:

2004

Language:

english

File:

PDF, 264 KB

english, 2004

46

Montacin and cis -Montacin, Two New Cytotoxic Monotetrahydrofuran Annonaceous Acetogenins from Annona m ontana

Liaw, Chih-Chuang, Chang, Fang-Rong, Wu, Yang-Chang, Wang, Hui-Kang, Nakanishi, Yuka, Bastow, Kenneth F., Lee, Kuo-Hsiung

Journal:

Journal of Natural Products

Year:

2004

Language:

english

File:

PDF, 100 KB

english, 2004

47

Computer Software Reviews.

Journal:

Journal of Chemical Information and Modeling

Year:

1992

Language:

english

File:

PDF, 317 KB

english, 1992

48

Structure and stereochemistry of amorphispironone, a novel cytotoxic spironone type rotenoid from Amorpha fruticosa

Li, Leping, Wang, Hui-Kang, Fujioka, Toshihiro, Chang, Jer-Jang, Kozuka, Mutsuo, Konoshima, Takao, Estes, James A., McPhail, Donald R., McPhail, Andrew T., Lee, Kuo-Hsiung

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1991

Language:

english

File:

PDF, 224 KB

english, 1991

49

Characterization of the modified chitosan membrane cross-linked with genipin for the cultured corneal epithelial cells

Li, Ya-Han, Cheng, Ching-Yi, Wang, Nan-Kai, Tan, Hsin-Yuan, Tsai, Yueh-Ju, Hsiao, Ching-Hsi, Ma, David Hui-Kang, Yeh, Lung-Kun

Journal:

Colloids and Surfaces B: Biointerfaces

Year:

2015

Language:

english

File:

PDF, 2.71 MB

english, 2015

50

Generation of Endostatin by Matrix Metalloproteinase and Cathepsin from Human Limbocorneal Epithelial Cells Cultivated on Amniotic Membrane

Ma, David Hui-Kang, Yao, Jeng-Yuan, Kuo, Ming-Tse, See, Lai-Chu, Lin, Kuei-Ying, Chen, Shao-Chun, Chen, Jan-Kan, Chao, An-Shine, Wang, Su-Fang, Lin, Ken-Kuo

Journal:

Investigative Ophthalmology & Visual Science

Year:

2007

Language:

english

File:

PDF, 249 KB

english, 2007